\ˈɛn wˈɒn θˈa͡ʊzənd sˈɪkshˈʌndɹədən θˈɜːtinˈa͡ɪn ˈe͡ɪ], \ˈɛn wˈɒn θˈaʊzənd sˈɪkshˈʌndɹədən θˈɜːtinˈaɪn ˈeɪ], \ˈɛ_n w_ˈɒ_n θ_ˈaʊ_z_ə_n_d s_ˈɪ_k_s_h_ˈʌ_n_d_ɹ_ə_d_ə_n θ_ˈɜː_t_i_n_ˈaɪ_n ˈeɪ]\
Definitions of EN1639A
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Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
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ATP Binding Cassette, Sub Family B Proteins
- A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.