EARLY ONSET ALZHEIMER DISEASE
\ˈɜːlɪ ˈɒnsɛt ˈaltsa͡ɪmə dɪzˈiːz], \ˈɜːlɪ ˈɒnsɛt ˈaltsaɪmə dɪzˈiːz], \ˈɜː_l_ɪ_ ˈɒ_n_s_ɛ_t ˈa_l_t_s_aɪ_m_ə d_ɪ_z_ˈiː_z]\
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A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgement, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
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