DNA INJURY
\dˌiːˌɛnˈe͡ɪ ˈɪnd͡ʒəɹi], \dˌiːˌɛnˈeɪ ˈɪndʒəɹi], \d_ˌiː__ˌɛ_n_ˈeɪ ˈɪ_n_dʒ_ə_ɹ_i]\
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Drug- or radiation-induced injuries in DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions which interfere with replication and transcription, as well as point mutations which disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA REPAIR). If the damage is extensive, it can induce apoptosis.
By DataStellar Co., Ltd