CYTOCHROME P 450 CYP2E1
\sˈa͡ɪtəkɹˌə͡ʊm pˈiː fˈɔːhˈʌndɹədən fˈɪfti sˌiːwˌa͡ɪpˈiː tˈuː ˈiː wˈɒn], \sˈaɪtəkɹˌəʊm pˈiː fˈɔːhˈʌndɹədən fˈɪfti sˌiːwˌaɪpˈiː tˈuː ˈiː wˈɒn], \s_ˈaɪ_t_ə_k_ɹ_ˌəʊ_m p_ˈiː f_ˈɔː_h_ˈʌ_n_d_ɹ_ə_d_ə_n f_ˈɪ_f_t_i s_ˌiː_w_ˌaɪ_p_ˈiː t_ˈuː ˈiː w_ˈɒ_n]\
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A polymorphic enzyme that activates carcinogenic N-nitrosamines, benzene, urethane, and other low molecular weight compounds. It is inducible by ethanol and metabilizes alcohol. Experimentally, it is used to study the effects of ethanol usage and withdrawal via enzyme markers such as N-nitrosodimethylamine demethylase. (Pharmacogenetics 1995;5 Spec No:S141-4) EC 1.5.99.-.
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Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.