CD10 ANTIGEN
\sˌiːdˈiː tˈɛn ˈantɪd͡ʒˌɛn], \sˌiːdˈiː tˈɛn ˈantɪdʒˌɛn], \s_ˌiː_d_ˈiː t_ˈɛ_n ˈa_n_t_ɪ_dʒ_ˌɛ_n]\
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Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA), an important marker in the diagnosis of human acute lymphocytic leukemia. EC 3.4.24.11.
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