SPINOPONTINE ATROPHIES
\spˈɪnəpˌɒntiːn ˈatɹəfɪz], \spˈɪnəpˌɒntiːn ˈatɹəfɪz], \s_p_ˈɪ_n_ə_p_ˌɒ_n_t_iː_n ˈa_t_ɹ_ə_f_ɪ_z]\
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Disorders characterized by an abnormal reduction in muscle volume due to a decrease in the size or number of muscle fibers. Atrophy may result from diseases intrinsic to muscle tissue (e.g., MUSCULAR DYSTROPHY) or secondary to PERIPHERAL NERVOUS SYSTEM DISEASES that impair innervation to muscle tissue (e.g., MUSCULAR ATROPHY, SPINAL).
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.