RENIN ANGIOTENSIN SYSTEM
\ɹɪnˈɪn ˈaŋɡɪˌə͡ʊtənsˌɪn sˈɪstəm], \ɹɪnˈɪn ˈaŋɡɪˌəʊtənsˌɪn sˈɪstəm], \ɹ_ɪ_n_ˈɪ_n ˈa_ŋ_ɡ_ɪ__ˌəʊ_t_ə_n_s_ˌɪ_n s_ˈɪ_s_t_ə_m]\
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A system consisting of renin, angiotensin-converting enzyme, and angiotensin II. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming angiotensin I. The converting enzyme contained in the lung acts on angiotensin I in the plasma converting it to angiotensin II, the most powerful directly pressor substance known. It causes contraction of the arteriolar smooth muscle and has other indirect actions mediated through the adrenal cortex.
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