PHOTOSENSITIVITY DISORDER
\fˌə͡ʊtə͡ʊsˌɛnsɪtˈɪvɪti dɪsˈɔːdə], \fˌəʊtəʊsˌɛnsɪtˈɪvɪti dɪsˈɔːdə], \f_ˌəʊ_t_əʊ_s_ˌɛ_n_s_ɪ_t_ˈɪ_v_ɪ_t_i d_ɪ_s_ˈɔː_d_ə]\
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Abnormal responses to sunlight or artificial light due to extreme reactivity of light-absorbing molecules in tissues. It refers almost exclusively to skin photosensitivity, including sunburn, reactions due to repeated prolonged exposure in the absence of photosensitizing factors, and reactions requiring photosensitizing factors such as photosensitizing agents and certain diseases. With restricted reference to skin tissue, it does not include photosensitivity of the eye to light, as in photophobia or photosensitive epilepsy.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.