NEUTRAL ENDOPEPTIDASE
\njˈuːtɹə͡l ˈɛndə͡ʊpˌɛptɪdˌe͡ɪs], \njˈuːtɹəl ˈɛndəʊpˌɛptɪdˌeɪs], \n_j_ˈuː_t_ɹ_əl ˈɛ_n_d_əʊ_p_ˌɛ_p_t_ɪ_d_ˌeɪ_s]\
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Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA), an important marker in the diagnosis of human acute lymphocytic leukemia. EC 3.4.24.11.
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Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.