NEUROENDOCRINE CARCINOMAS
\njˈuːɹə͡ʊndˌɒkɹa͡ɪn kˌɑːsɪnˈə͡ʊməz], \njˈuːɹəʊndˌɒkɹaɪn kˌɑːsɪnˈəʊməz], \n_j_ˈuː_ɹ_əʊ_n_d_ˌɒ_k_ɹ_aɪ_n k_ˌɑː_s_ɪ_n_ˈəʊ_m_ə_z]\
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A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.