MONOSODIUM SALT SURAMIN
\mˌɒnə͡ʊsˈə͡ʊdi͡əm sˈɒlt sˈɜːɹɐmˌɪn], \mˌɒnəʊsˈəʊdiəm sˈɒlt sˈɜːɹɐmˌɪn], \m_ˌɒ_n_əʊ_s_ˈəʊ_d_iə_m s_ˈɒ_l_t s_ˈɜː_ɹ_ɐ_m_ˌɪ_n]\
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A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.