MICROBIAL COLLAGENASE
\ma͡ɪkɹˈə͡ʊbɪəl kˈɒle͡ɪd͡ʒnˌe͡ɪs], \maɪkɹˈəʊbɪəl kˈɒleɪdʒnˌeɪs], \m_aɪ_k_ɹ_ˈəʊ_b_ɪ__ə_l k_ˈɒ_l_eɪ_dʒ_n_ˌeɪ_s]\
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A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.
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