MENINGISMS
\mˈɛnɪŋɡˌɪzəmz], \mˈɛnɪŋɡˌɪzəmz], \m_ˈɛ_n_ɪ_ŋ_ɡ_ˌɪ_z_ə_m_z]\
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A condition characterized by neck stiffness, headache, and other symptoms suggestive of meningeal irritation, but without actual inflammation of the meninges (MENINGITIS). Spinal fluid pressure may be elevated but spinal fluid is normal. (DeJong, The Neurologic Examination, 4th ed, p673)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.