MATRIX METALLOPROTEINASE 3
\mˈe͡ɪtɹɪks mˈɛtə͡lˌɒpɹə͡ʊtˌɪne͡ɪs θɹˈiː], \mˈeɪtɹɪks mˈɛtəlˌɒpɹəʊtˌɪneɪs θɹˈiː], \m_ˈeɪ_t_ɹ_ɪ_k_s m_ˈɛ_t_əl_ˌɒ_p_ɹ_əʊ_t_ˌɪ_n_eɪ_s θ_ɹ_ˈiː]\
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An extracellular endopeptidase of vertebrate tissues similar to INTERSTITIAL COLLAGENASE. It digests proteoglycan, fibronectin, collagen types III, IV, V, and IX, and activates procollagenase. (Enzyme Nomenclature, 1992) EC 3.4.24.17.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.