MAD HATTER DISEASE
\mˈad hˈatə dɪzˈiːz], \mˈad hˈatə dɪzˈiːz], \m_ˈa_d h_ˈa_t_ə d_ɪ_z_ˈiː_z]\
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Neurologic disorders associated with exposure to inorganic and organic forms of MERCURY. Acute intoxication may be associated with gastrointestinal disturbances, mental status changes, and PARAPARESIS. Chronic exposure to inorganic mercury usually occurs in industrial workers, and manifests as mental confusion, prominent behavioral changes (including psychosis), DYSKINESIAS, and NEURITIS. Alkyl mercury poisoning may occur through ingestion of contaminated seafood or grain, and its characteristic features include POLYNEUROPATHY; ATAXIA; vision loss; NYSTAGMUS; and DEAFNESS. (From Joynt, Clinical Neurology, 1997, Ch20, pp10-15)
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Immunologic Desensitization
- Immunosuppression by the administration increasing doses antigen. Though exact mechanism is not clear, therapy results increase in serum levels of allergen-IMMUNOGLOBULIN G, suppression specific IgE, and an suppressor T-cell activity.