E BOX SEQUENCE
\ˈiː bˈɒks sˈiːkwəns], \ˈiː bˈɒks sˈiːkwəns], \ˈiː b_ˈɒ_k_s s_ˈiː_k_w_ə_n_s]\
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DNA locations with the consensus sequence CANNTG. ENHANCER ELEMENTS (GENETICS) may contain multiple copies of this element. E-boxes play a regulatory role in the control of transcription. They bind with basic helix-loop-helix (bHLH) type TRANSCRIPTION FACTORS. Binding specificity is determined by the specific bHLH heterodimer or homodimer combination and by the specific nucleotides at the 3rd and 4th position of the E-box sequence.
By DataStellar Co., Ltd
