DIT RECEPTORS
\dˌiːˌa͡ɪtˈiː ɹɪsˈɛptəz], \dˌiːˌaɪtˈiː ɹɪsˈɛptəz], \d_ˌiː__ˌaɪ_t_ˈiː ɹ_ɪ_s_ˈɛ_p_t_ə_z]\
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Proteins, usually found in the nucleus, that specifically bind thyroid hormones and regulate DNA transcription. These proteins, termed c-erbA, are activated by hormones and cause differentiation of erythroid progenitor cells which irreversibly lose proliferative potential. Thus c-erbA proteins act as growth suppressors. The c-erbA proteins are encoded by at least two genes, c-erbA alpha and c-erbA beta. Each of these has two isoforms. Mutations in the ligand-binding domain of the beta form causes THYROID HORMONE RESISTANCE SYNDROME.
By DataStellar Co., Ltd
