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An abundant mitochondrial protein and integral component of the inner mitochondrial membrane. It facilitates the exchange of ADP and ATP between the cytosol and the mitochondria, thereby linking the subcellular compartment of ATP production to those of ATP utilization. It has several known isoforms, ANT1, ANT2, & ANT3 that should not be confused with the Ant1 and Ant2 proteins that are encoded by the ant gene, which is an antirepressor gene that antagonizes the C1 repressor. EC 2.7.7.-.