RESISTANT OVARY SYNDROME
\ɹɪsˈɪstənt ˈə͡ʊvəɹi sˈɪndɹə͡ʊm], \ɹɪsˈɪstənt ˈəʊvəɹi sˈɪndɹəʊm], \ɹ_ɪ_s_ˈɪ_s_t_ə_n_t ˈəʊ_v_ə_ɹ_i s_ˈɪ_n_d_ɹ_əʊ_m]\
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Premature failure of ovulation associated with hypergonadotropinism and hypoestrogenism in women under the age of 40. The etiology appears to be multifactorial and many cases are idiopathic. When follicles are present but the ovaries are unable to respond to gonadotropins, resistant ovary syndrome results and this may be associated with autoimmune disease. Even when there is a loss of ovarian follicles, it is not always complete. Permanent and irreversible loss of follicles is termed premature menopause (MENOPAUSE, PREMATURE).
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.