PITYRIASIS LICHENOIDES
\pˈɪtɪɹˌɪɐsˌiz lˈɪt͡ʃənˌɔ͡ɪdz], \pˈɪtɪɹˌɪɐsˌiz lˈɪtʃənˌɔɪdz], \p_ˈɪ_t_ɪ_ɹ_ˌɪ__ɐ_s_ˌi_z l_ˈɪ_tʃ_ə_n_ˌɔɪ_d_z]\
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A subgroup of PARAPSORIASIS itself divided into acute and chronic forms. The acute form is characterized by the abrupt onset of a generalized, reddish-brown, maculopapular eruption. Lesions may be vesicular, hemorrhagic, crusted, or necrotic. Histologically the disease is characterized by epidermal necrolysis. The chronic form shows milder skin changes with necrosis. An important variant of the chronic form is LYMPHOMATOID PAPULOSIS.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.