PERONEAL MUSCULAR ATROPHIES
\pˈɛɹə͡ʊnə͡l mˈʌskjʊləɹ ˈatɹəfɪz], \pˈɛɹəʊnəl mˈʌskjʊləɹ ˈatɹəfɪz], \p_ˈɛ_ɹ_əʊ_n_əl m_ˈʌ_s_k_j_ʊ_l_ə_ɹ ˈa_t_ɹ_ə_f_ɪ_z]\
Sort: Oldest first
-
A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.