P GLYCOPROTEINS
\pˈiː ɡlˈa͡ɪkəpɹˌə͡ʊtiːnz], \pˈiː ɡlˈaɪkəpɹˌəʊtiːnz], \p_ˈiː ɡ_l_ˈaɪ_k_ə_p_ɹ_ˌəʊ_t_iː_n_z]\
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A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
By DataStellar Co., Ltd
