P GP
\pˈiː d͡ʒˌiːpˈiː], \pˈiː dʒˌiːpˈiː], \p_ˈiː dʒ_ˌiː_p_ˈiː]\
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A 170 kD transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
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Word of the day
hydromorphic
- [Greek] Structurally adapted to an aquatic environment, as organs of water plants.