MICROORGANISM Z
\mˌa͡ɪkɹə͡ʊˈɔːɡənˌɪzəm zˈɛd], \mˌaɪkɹəʊˈɔːɡənˌɪzəm zˈɛd], \m_ˌaɪ_k_ɹ_əʊ_ˈɔː_ɡ_ə_n_ˌɪ_z_ə_m z_ˈɛ_d]\
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An order of obligately intracellular bacteria that have the chlamydia-like developmental cycle of replication. This is a two-stage cycle that includes a metabolically inactive infectious form, and a vegetative form that replicates by binary fission. Members of Chlamydiales are disseminated by aerosol or by contact. There are at least four recognized families: CHLAMYDIACEAE, Parachlamydiaceae, Simkaniaceae, and Waddliaceae.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.