ISOCHROMOSOMES
\ˈa͡ɪsəkɹˌə͡ʊməsˌə͡ʊmz], \ˈaɪsəkɹˌəʊməsˌəʊmz], \ˈaɪ_s_ə_k_ɹ_ˌəʊ_m_ə_s_ˌəʊ_m_z]\
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Metacentric chromosomes produced during meiosis or mitosis when the centromere splits transversely instead of longitudinally. The chromosomes produced by this abnormal division are one chromosome having the two long arms of the original chromosome, but no short arms, and the other chromosome consisting of the two short arms and no long arms. Each of these isochromosomes constitutes a simultaneous duplication and deletion.
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.