\ɪmpˈɔːtɪn ˈalfə], \ɪmpˈɔːtɪn ˈalfə], \ɪ_m_p_ˈɔː_t_ɪ_n ˈa_l_f_ə]\
Definitions of IMPORTIN ALPHA
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Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNAL of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUCCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
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Marcy, Randolph B.
- (1812-1887), served Mexican War, and brevetted major-general for services during Civil War. From 1869 to 1881 he was inspector-general. published "Exploration of the Red River" in 1852.