IMPORTINS
\ɪmpˈɔːtɪnz], \ɪmpˈɔːtɪnz], \ɪ_m_p_ˈɔː_t_ɪ_n_z]\
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A family of proteins involved in nucleocytoplasmic transport. Karyopherins are heteromeric molecules composed two major types of components, ALPHA KARYOPERINS and BETA KARYOPHERINS, that function together to transport molecules through the NUCLEAR PORE COMPLEX. Several other proteins such as RAN GTP BINDING PROTEIN and CELLULAR APOPTOSIS SUCCEPTIBILITY PROTEIN bind to karyopherins and participate in the transport process.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.