IMMUNOSUPPRESSION (PHYSIOLOGY)
\ɪmjˌuːnəsəpɹˈɛʃən fˌɪzɪˈɒləd͡ʒi], \ɪmjˌuːnəsəpɹˈɛʃən fˌɪzɪˈɒlədʒi], \ɪ_m_j_ˌuː_n_ə_s_ə_p_ɹ_ˈɛ_ʃ_ə_n__ f_ˌɪ_z_ɪ__ˈɒ_l_ə_dʒ_i]\
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The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
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Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.