GR43175

\d͡ʒˌiːˈɑː fˈɔːtiθɹˈiː θˈa͡ʊzənd wˈɒnhˈʌndɹədən sˈɛvəntifˈa͡ɪv], \d‍ʒˌiːˈɑː fˈɔːtiθɹˈiː θˈa‍ʊzənd wˈɒnhˈʌndɹədən sˈɛvəntifˈa‍ɪv], \dʒ_ˌiː__ˈɑː f_ˈɔː_t_i_θ_ɹ_ˈiː θ_ˈaʊ_z_ə_n_d_ w_ˈɒ_n_h_ˈʌ_n_d_ɹ_ə_d_ə_n s_ˈɛ_v_ə_n_t_i_f_ˈaɪ_v]\

Definitions of GR43175

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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