DNA RESTRICTION MODIFICATION ENZYMES
\dˌiːˌɛnˈe͡ɪ ɹɪstɹˈɪkʃən mˌɒdɪfɪkˈe͡ɪʃən ˈɛnza͡ɪmz], \dˌiːˌɛnˈeɪ ɹɪstɹˈɪkʃən mˌɒdɪfɪkˈeɪʃən ˈɛnzaɪmz], \d_ˌiː__ˌɛ_n_ˈeɪ ɹ_ɪ_s_t_ɹ_ˈɪ_k_ʃ_ə_n m_ˌɒ_d_ɪ_f_ɪ_k_ˈeɪ_ʃ_ə_n ˈɛ_n_z_aɪ_m_z]\
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Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are closely related in their specificity and protect the DNA of a given bacterial species. The methylase adds methyl groups to adenine or cytosine residues in the same target sequence that constitutes the restriction enzyme binding site. The methylation renders the target site resistant to restriction, thereby protecting DNA against cleavage.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.