CYTOCHROME P 450 OXYGENASE
\sˈa͡ɪtəkɹˌə͡ʊm pˈiː fˈɔːhˈʌndɹədən fˈɪfti ˈɒksɪd͡ʒənˌe͡ɪs], \sˈaɪtəkɹˌəʊm pˈiː fˈɔːhˈʌndɹədən fˈɪfti ˈɒksɪdʒənˌeɪs], \s_ˈaɪ_t_ə_k_ɹ_ˌəʊ_m p_ˈiː f_ˈɔː_h_ˈʌ_n_d_ɹ_ə_d_ə_n f_ˈɪ_f_t_i_ ˈɒ_k_s_ɪ_dʒ_ə_n_ˌeɪ_s]\
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Isozymes which are key components of the mixed-function oxidase system responsible for the biotransformation of many foreign compounds to mutagens and carcinogens. Most mammals have several distantly related phenobarbital-inducible gene subfamilies. EC 1.13.-.
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Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.