CYCLOSPORINES
\sˈa͡ɪkləspˌɔːɹiːnz], \sˈaɪkləspˌɔːɹiːnz], \s_ˈaɪ_k_l_ə_s_p_ˌɔː_ɹ_iː_n_z]\
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A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.