CYCLOPHILIN A
\sˈa͡ɪkləfˌɪlɪn ˈe͡ɪ], \sˈaɪkləfˌɪlɪn ˈeɪ], \s_ˈaɪ_k_l_ə_f_ˌɪ_l_ɪ_n ˈeɪ]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.