CALPAIN I
\kˈalpe͡ɪn ˈa͡ɪ], \kˈalpeɪn ˈaɪ], \k_ˈa_l_p_eɪ_n ˈaɪ]\
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Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including neuropeptides, cytoskeletal proteins, proteins from smooth muscle, cardiac muscle, liver, platelets and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase.
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