ALLELIC LOSS
\alˈɛlɪk lˈɒs], \alˈɛlɪk lˈɒs], \a_l_ˈɛ_l_ɪ_k l_ˈɒ_s]\
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The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair. It is detected when heterozygous markers for a locus appear monomorphic because one of the alleles was deleted. When this occurs at a tumor suppressor gene locus where one of the alleles is already abnormal, it can result in neoplastic transformation.
By DataStellar Co., Ltd
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