XANTHOMATOUS MENINGIOMA
\zˌanθəmˈatəs mˌɛnɪŋɡɪˈə͡ʊmə], \zˌanθəmˈatəs mˌɛnɪŋɡɪˈəʊmə], \z_ˌa_n_θ_ə_m_ˈa_t_ə_s m_ˌɛ_n_ɪ_ŋ_ɡ_ɪ__ˈəʊ_m_ə]\
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A relatively common neoplasm of the central nervous system that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and spinal canal. They tend to present in the fourth to sixth decades of life with signs indicative of a slowly progressive mass lesion. Specific clinical manifestations depend on the location of the tumor, but may include INTRACRANIAL HYPERTENSION, cranial neuropathies, ataxia, and other focal neurologic signs. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
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Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.