WATSON SYNDROME
\wˈɒtsən sˈɪndɹə͡ʊm], \wˈɒtsən sˈɪndɹəʊm], \w_ˈɒ_t_s_ə_n s_ˈɪ_n_d_ɹ_əʊ_m]\
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An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic neural crest. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18)
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Vertebral Artery Dissection
- Dissection wall artery, leading to formation an aneurysm that occlude vessel. Thrombus give rise emboli. Cervical fractures or related NECK INJURIES and CRANIOCEREBRAL TRAUMA are commonly associated conditions, although this process may occur spontaneously. Ischemia, infarction, hemorrhage in the vascular distribution of affected vertebral artery complicate condition.