\ʌnkˈʌstəməɹi], \ʌnkˈʌstəməɹi], \ʌ_n_k_ˈʌ_s_t_ə_m_ə_ɹ_i]\

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Proto Oncogene Proteins c erbB 2

  • cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.
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