TUMOR SUPPRESSOR GENE
\tjˈuːmə səpɹˈɛsə d͡ʒˈiːn], \tjˈuːmə səpɹˈɛsə dʒˈiːn], \t_j_ˈuː_m_ə s_ə_p_ɹ_ˈɛ_s_ə dʒ_ˈiː_n]\
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Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
By DataStellar Co., Ltd
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.