TROPICAL SPASTIC PARAPARESES
\tɹˈɒpɪkə͡l spˈastɪk pˈaɹəpˌe͡əsiːz], \tɹˈɒpɪkəl spˈastɪk pˈaɹəpˌeəsiːz], \t_ɹ_ˈɒ_p_ɪ_k_əl s_p_ˈa_s_t_ɪ_k p_ˈa_ɹ_ə_p_ˌeə_s_iː_z]\
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A subacute paralytic myeloneuropathy occurring endemically in tropical areas such as the Caribbean, Colombia, India, and Africa, as well as in the southwestern region of Japan; associated with infection by human T-cell leukemia virus type I (HUMAN T-LYMPHOTROPIC VIRUS 1). Clinical manifestations include a slowly progressive spastic weakness of the legs, increased reflexes, Babinski signs, incontinence, and loss of vibratory and position sensation. On pathologic examination inflammatory, demyelination, and necrotic lesions may be found in the spinal cord. (Adams et al., Principles of Neurology, 6th ed, p1239)
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