\tɹa͡ɪsˈa͡ɪklɪk ˌantɪdɪpɹˈɛsənts], \tɹaɪsˈaɪklɪk ˌantɪdɪpɹˈɛsənts], \t_ɹ_aɪ_s_ˈaɪ_k_l_ɪ_k ˌa_n_t_ɪ_d_ɪ_p_ɹ_ˈɛ_s_ə_n_t_s]\
Definitions of TRICYCLIC ANTIDEPRESSANTS
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Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
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