TNF BETA
\tˌiːˌɛnˈɛf bˈiːtə], \tˌiːˌɛnˈɛf bˈiːtə], \t_ˌiː__ˌɛ_n_ˈɛ_f b_ˈiː_t_ə]\
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Soluble substance released by lymphocytes activated by antigens or T-cell mitogens, that is cytotoxic to other cells. It is involved in allergies and chronic inflammatory diseases. Lymphotoxin is antigenically distinct from tumor necrosis factor-alpha (TUMOR NECROSIS FACTOR), though they both share a common receptor, biological activities, and significant amino acid sequences.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.