TAKATSUKI SYNDROME
\tˌakɐtsˈuːki sˈɪndɹə͡ʊm], \tˌakɐtsˈuːki sˈɪndɹəʊm], \t_ˌa_k_ɐ_t_s_ˈuː_k_i s_ˈɪ_n_d_ɹ_əʊ_m]\
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A multisystemic disorder characterized by a sensorimotor polyneuropathy (POLYNEUROPATHIES), organomegaly, endocrinopathy, monoclonal gammopathy, and pigmentary skin changes. Other clinical features which may be present include EDEMA; CACHEXIA; microangiopathic glomerulopathy; pulmonary hypertension (HYPERTENSION, PULMONARY); cutaneous necrosis; THROMBOCYTOSIS; and POLYCYTHEMIA. This disorder is frequently associated with osteosclerotic myeloma. (From Adams et al., Principles of Neurology, 6th ed, p1335; Rev Med Interne 1997;18 (7):553-62)
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EF 1H
- Peptide elongation factor 1 multisubunit protein that responsible GTP-dependent binding of aminoacyl-tRNAs eukaryotic ribosomes. alpha 1alpha) binds tRNA transfers it ribosome in a process linked to GTP hydrolysis. The beta and delta subunits (1beta, EF-1delta) are involved exchanging GDP for GTP. gamma subunit (1gamma) is structural component.