SV40 T PROTEINS
\ˌɛsvˈiː fˈɔːti tˈiː pɹˈə͡ʊtiːnz], \ˌɛsvˈiː fˈɔːti tˈiː pɹˈəʊtiːnz], \ˌɛ_s_v_ˈiː f_ˈɔː_t_i t_ˈiː p_ɹ_ˈəʊ_t_iː_n_z]\
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Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.