SUCCINATE COA LIGASES
\səksɪnˈe͡ɪt kˈə͡ʊ ɐ lˈɪɡe͡ɪsɪz], \səksɪnˈeɪt kˈəʊ ɐ lˈɪɡeɪsɪz], \s_ə_k_s_ɪ_n_ˈeɪ_t k_ˈəʊ ɐ l_ˈɪ_ɡ_eɪ_s_ɪ_z]\
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Enzymes that catalyze the first step leading to the oxidation of succinic acid by the reversible formation of succinyl-CoA from succinate and CoA with the concomitant cleavage of ATP to ADP (EC 6.2.1.5) or GTP to GDP (EC 6.2.1.4) and orthophosphate. Itaconate can act instead of succinate and ITP instead of GTP.EC 6.2.1.-.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.