STRUCTURE ACTIVITY RELATIONSHIP
\stɹˈʌkt͡ʃəɹ aktˈɪvɪti ɹɪlˈe͡ɪʃənʃˌɪp], \stɹˈʌktʃəɹ aktˈɪvɪti ɹɪlˈeɪʃənʃˌɪp], \s_t_ɹ_ˈʌ_k_tʃ_ə_ɹ a_k_t_ˈɪ_v_ɪ_t_i ɹ_ɪ_l_ˈeɪ_ʃ_ə_n_ʃ_ˌɪ_p]\
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The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Other factors contributing to structure-activity relationship include chemical reactivity, electronic effects, resonance, and inductive effects.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.