STEROID 12 HYDROXYLASE
\stˈɛɹɔ͡ɪd twˈɛlv hˈa͡ɪdɹəksˌɪle͡ɪs], \stˈɛɹɔɪd twˈɛlv hˈaɪdɹəksˌɪleɪs], \s_t_ˈɛ_ɹ_ɔɪ_d t_w_ˈɛ_l_v h_ˈaɪ_d_ɹ_ə_k_s_ˌɪ_l_eɪ_s]\
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A steroid hydroxylase found in liver microsomes. It catalyzes the 12-hydroxylation of steroids in the presence of NADPH, cytochrome P-450, and molecular oxygen. It is an important enzyme in the synthesis of cholic acid from cholesterol in the liver. EC 1.14.99.-.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.