SPORADIC INCLUSION BODY MYOSITIS
\spɔːɹˈadɪk ɪnklˈuːʒən bˈɒdi mˌa͡ɪəsˈa͡ɪtɪs], \spɔːɹˈadɪk ɪnklˈuːʒən bˈɒdi mˌaɪəsˈaɪtɪs], \s_p_ɔː_ɹ_ˈa_d_ɪ_k ɪ_n_k_l_ˈuː_ʒ_ə_n b_ˈɒ_d_i m_ˌaɪ_ə_s_ˈaɪ_t_ɪ_s]\
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Progressive myopathies characterized by the presence of inclusion bodies on muscle biopsy. Sporadic and hereditary forms have been described. The sporadic form is an acquired, adult-onset inflammatory vacuolar myopathy affecting proximal and distal muscles. Familial forms usually begin in childhood and lack inflammatory changes. Both forms feature intracytoplasmic and intranuclear inclusions in muscle tissue. (Adams et al., Principles of Neurology, 6th ed, pp1409-10)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.