SPONTANEOUS INTRACRANIAL HYPOTENSION
\spɒntˈe͡ɪni͡əs ˌɪntɹəkɹˈe͡ɪnɪəl hˌa͡ɪpə͡ʊtˈɛnʃən], \spɒntˈeɪniəs ˌɪntɹəkɹˈeɪnɪəl hˌaɪpəʊtˈɛnʃən], \s_p_ɒ_n_t_ˈeɪ_n_iə_s ˌɪ_n_t_ɹ_ə_k_ɹ_ˈeɪ_n_ɪ__ə_l h_ˌaɪ_p_əʊ_t_ˈɛ_n_ʃ_ə_n]\
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Reduction of CEREBROSPINAL FLUID pressure characterized clinically by HEADACHE which is maximal in an upright posture and occasionally by an abducens nerve palsy (see ABDUCENS NERVE DISEASES), neck stiffness, hearing loss (see DEAFNESS), NAUSEA, and other symptoms. This condition may be spontaneous or secondary to SPINAL PUNCTURE; NEUROSURGICAL PROCEDURES; DEHYDRATION; UREMIA; trauma (see also CRANIOCEREBRAL TRAUMA); and other processes. Chronic hypotension may be associated with subdural hematomas (see HEMATOMA, SUBDURAL) or hygromas. (From Semin Neurol 1996 Mar;16 (1):5-10; Adams et al., Principles of Neurology, 6th ed, pp637-8)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.