SPLEEN FOCUS FORMING VIRUS
\splˈiːn fˈə͡ʊkəs fˈɔːmɪŋ vˈa͡ɪɹəs], \splˈiːn fˈəʊkəs fˈɔːmɪŋ vˈaɪɹəs], \s_p_l_ˈiː_n f_ˈəʊ_k_ə_s f_ˈɔː_m_ɪ_ŋ v_ˈaɪ_ɹ_ə_s]\
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Strains of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) that are replication-defective and rapidly transforming. The envelope gene plays an essential role in initiating erythroleukemia (LEUKEMIA, ERYTHROBLASTIC, ACUTE), manifested by splenic foci, SPLENOMEGALY, and POLYCYTHEMIA. Spleen focus-forming viruses are generated by recombination with other viral types.
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